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Genetic polymorphisms in MTHFR have been linked to cardiovascular diseases, stroke, metabolic syndrome, psychiatric disorders, and certain types of cancer

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Although omics profiling has substantially expanded our understanding of these processes, much of the literature remains single-layer, making it difficult to distinguish causal biology from timing, protocol, and tissue-composition effects

The promising effects observed in vitro often require sophisticated formulations (e.g., with piperine, nanoparticles) to be partially translated in humans, raising questions about the efficacy of simple dietary intake or standard extracts (50)

There are several barriers to cure, one of which involves covalently closed circular DNA, a sort of viral chromosome in the liver cells of an infected person