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VC has been shown to reduce neuronal death by down-regulating the activation of Bcl2-associated X (Bax) and capcase3 while simultaneously increasing the expression of B-cell lymphoma-2 (Bcl-2)

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Numerous studies, such as genome-wide association studies (GWAS), have identified significance to the expression of numerous genes related to -cell function and insulin secretion

TABLE 1 Summary of the writers, readers, and erasers of lysine lactylation and their corresponding sites and functions under different conditions

ROS can act on proteins to cause side-chain oxidation, backbone fragmentation, unfolding, and misfolding, all resulting in loss of activity [25]