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doi: 10.18632/oncotarget.16170 121

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Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

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Naunyn Schmiedebergs Arch Pharmacol 397(8):61656175 Colwell MJ, Tagomori H, Chapman S, Gillespie AL, Cowen PJ, Harmer CJ, Murphy SE (2022) Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research

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Monitor Your Iodine Intake While iodine is crucial for thyroid health, excessive intake can exacerbate autoimmune responses in Hashimoto's

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Conceptually, these pathways should be viewed not as isolated modules but as an integrated redox defense network, in which failure of one arm can be partially compensated by the others until a critical threshold of lipid peroxide accumulation is exceeded

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