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doi: 10.18632/oncotarget.16170 121

Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

Naunyn Schmiedebergs Arch Pharmacol 397(8):61656175 Colwell MJ, Tagomori H, Chapman S, Gillespie AL, Cowen PJ, Harmer CJ, Murphy SE (2022) Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research

Monitor Your Iodine Intake While iodine is crucial for thyroid health, excessive intake can exacerbate autoimmune responses in Hashimoto's

Conceptually, these pathways should be viewed not as isolated modules but as an integrated redox defense network, in which failure of one arm can be partially compensated by the others until a critical threshold of lipid peroxide accumulation is exceeded