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The challenge lies in the bidirectional regulation of pyroptosis, where its intensity must be carefully controlled to prevent inflammatory storms

Targeting PD-L1 initiates effective antitumor immunity in a murine model of cushing disease

Under physiological or subtoxic lipid peroxidation rates, cells survive by upregulation of antioxidant pathways and proteins, whereas, at toxic concentration levels, cells induce apoptosis, eventually leading to cellular damage (32)

Udell JA, Jones WS, Petrie MC, Harrington J, Anker SD, Bhatt DL, Hernandez AF, Butler J (2022) Sodium glucose cotransporter-2 inhibition for acute myocardial infarction: JACC review topic of the week