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[DOI] [PubMed] [Google Scholar] 167.Lam K H, Ma S

10.1186/s13073-016-0299-7 Genome Med

When NAD levels decline, it results in a decrease in cellular energy, which can also be described as mitochondrial dysfunction a condition that is implicated in most chronic illnesses, including diabetes, autoimmune disorders, Alzheimers, multiple sclerosis and many more

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Among the genes identified is a nonheme, -ketoglutarate-dependent oxygenase that catalyzes oxidative C-C bond formation that converts the intermediate ()-yatein ( 326 ) to the fused 5-6-6-5 tetracyclic framework in ()-deoxypodophyllotoxin ( 327 ) that is the characteristic core of podophyllotoxins and etoposide