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MSA-2 synchronously activates STING in tumor cells and dendritic cells, and combines with DOX, induces ICD, resulting in persistent systemic immune surveillance and significantly inhibiting postoperative recurrence and distant metastasis

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106 Very interestingly, in a phase 1 clinical trial, treatment with BCL-2 inhibitor ABT-199 achieved complete responses in 5 of 32 AML patients, the majority of whom had relapsed/refractory leukemic disease
