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However, when compared to traditional orally administrated drugs, the pharmacokinetic properties of L-carnitine are complex, since it exhibits poor intestinal absorption and bioavailability, very high renal clearance, and uptake into tissues through a high affinity transporter [13]

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No benefit was discerned in either the primary composite endpoint or any secondary endpoint despite the fact that pemafibrate reduced triglycerides 26.2%, VLDL 25.8%, remnant lipoprotein cholesterol 25.6%, and apo CIII by 27.6%

doi: 10.3349/ymj.2016.57.4.865

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