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Unreconstituted powder should be stored frozen at -20 degrees Celsius for maximum stability

The combination is most useful for patients with one or more of the following: BMI of 30 or higher , or BMI 27 with at least one weight-related condition such as type 2 diabetes, hypertension, or sleep apnea History of fatigue, low mood, or brain fog on previous diets or weight loss attempts Metformin use for type 2 diabetes or pre-diabetes (chronic metformin reduces B12) Long-term proton pump inhibitor use such as omeprazole, pantoprazole, or lansoprazole Vegetarian or vegan diet with limited animal protein intake Adults over 50 , where B12 absorption naturally declines Active strength training or higher physical demands while on a calorie deficit Patients who dont fit any of these profiles can still take semaglutide alone, then add B12 if symptoms suggest it

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J Physiol Pharmacol 62:591599 Kumar V, Fischer M (2020) Expert opinion on fecal microbiota transplantation for the treatment of Clostridioides difficile infection and beyond

The barrel is marked clearly in one-unit increments (0100 for a 1 mL syringe), simplifying dose measurement