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Description
One important chemical found in the rhizomes of Rhamnus purshiana (as well as rhubarb and numerous other plants) is the anthraquinone emodin
Its particularly focused on visceral and abdominal adipose tissue, which is exactly the stubborn midsection fat patients complain about most

10.1016/j.freeradbiomed.2018.05.074 Free Radic

Calretinin-immunoreactive neurons in the human striatum

The anorexigenic neurotransmitters released by the inhibitory circuit decrease appetite, while the appetite-stimulatory circuit expresses orexigenic neurotransmitters which promote appetite