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Expansion of BMAT with caloric restriction can be blunted by overexpressing Wnt10b specifically in osteoblast lineage cells, likely by inhibiting the differentiation of skeletal progenitor cells into adipocytes (90)

Start at the lower end, check tolerance, and reassess after 812 weeks

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Compliance to the supplementation protocol was monitored by the research dietician who contacted participants on a weekly basis by phone

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