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(PubMed) Maitra I, Serbinova E, Tritschler HJ, Packer L

Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

Understanding the molecular synthesis of collagen is essential for understanding this pathophysiology of tendinopathies (see the nutrition page for more details), but in the final stages of collagen maturation, reactive aldol groups on hydroxylysine react non-enzymatically with sugar to create covalent glycosylated cross-links ("advanced glycation end-products") between fibrils that can add further strength to collagen fibers, but interestingly under states of cell death and inflammation the fibrils can become over-glycated by release of sugar and other contents from localized dying cells, which appears to impair the ability of newly-synthesized collagen fibers to bind to older fibers and thus impairs proper tendon regeneration, and this may explain the dramatic efficacy of treatments like shockwave therapy, PRF repair, peptide therapy, and new injectable investigational medications, which is an area of active ongoing research at ASOI (1) (2) (3) (4)

The strongest support comes from clinical evidence focused on treating vitamin B12 deficiency, not from general wellness claims What science supports The NIH Fact Sheet for Health Professionals shows that intramuscular B12 injections are effective at raising blood B12 levels and correcting deficiency
