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Neuroprotective action was also obtained due to acetyl-l-carnitine metabolisms into pyruvate, which is a source of energy for neurons [24, 25]
Thus, they end up in the physiological systems through various routes
doi: 10.1681/ASN.V133708
doi:10.1016/j.ymgme.2010.11.160 [CrossRef] 2
Interestingly, apoE2 and apoE3 are shown to induce proliferation of vascular endothelial cells while apoE4 decreases their proliferation [158], potentially contributing to the breakdown of the BBB
