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Contrary to FDAs assertion, the WHO (2003) did not conclude that [t]he highest estimate that WHO reports was a dose of 12 gs/day, for middle-aged individuals with approximately 30 amalgam surfaces (Ref 22)

807,808 However, off-target effects and genotoxicity remain significant concerns in the therapeutic use of CRISPR-Cas9

Neilan, H

however, there is still a noticeable lack of specific inhibitors directed against this enzyme
