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Taking into account (i) the anti-autoimmunity and anti-cancer properties of the omega-3 PUFA, (ii) the increasing incidence of both autoimmune thyroiditis and thyroid cancer worldwide, (iii) the predisposing role for thyroid cancer exerted by autoimmune thyroiditis, and (iv) the risk for developing metabolic and cardiovascular disorders conferred by both elevated/trendwise elevated serum TSH levels and thyroid autoimmunity, then there is enough rationale for the omega-3 PUFA as measures to contrast the appearance and/or duration of Hashimotos thyroiditis as well as to correct the slightly elevated serum TSH levels of subclinical hypothyroidism

Rajakovich LJ, Fu B, Bollenbach M, Balskus EP Proceedings of the National Academy of Sciences of the United States of America 2021

The endogenous production of creatine and enzymes such as arginine: glycine amidinotransferase (AGAT) is responsible for its production, which is facilitated in the kidney [71,72]