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doi: 10.1016/j.pmpp.2020.101556

This revealed similar (liver, kidney, spleen) or even reduced (blood cells) platinum levels in healthy as compared to malignant tissue in case of BSO-OxMal

[ 323 ] Instead, deletion of Progesterone receptor membrane component 2 (PGMRC2) in brown fat, an intracellular haem chaperone, decreases labile haem in the nucleus and improves the stability of BACH1, which is the haemresponsive transcriptional suppressor, resulting in higher fasting glycemia, reduced glucose tolerance and insulin sensitivity, hyperlipidemia, and exacerbated liver steatosis in mice with HFD

McLachlan SM, Rapoport B (2014) Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity