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Evolving Therapeutics in Multiple Myeloma Highly effective treatments are available in early-line settings of multiple myeloma management, such as proteasome inhibitors, immunomodulatory drugs (IMiDs), corticosteroids, and multiple drug combinations, including anti-CD38 antibodies, but treatment options for progressive disease following initial lines of therapy have historically been limited

Transl Med 8, 361ra139 (2016)

Importantly, cell viability was not affected, meaning the compound did not simply kill fat cells but changed their metabolic behavior