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A deficiency can manifest gradually through chronic exhaustion, persistent fatigue, and noticeably slower recovery after physical or mental exertion [8]

doi: 10.4103/atm.ATM_171_17 55 PasteurMCBiltonDHillATBritish Thoracic Society

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Direct-to-biology (D2B) approaches are generally defined as a set of strategies that aim at the biological study of chemical compounds without the need for post-synthesis purification, i.e., biological evaluation of the crude product 183,184
