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Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

Tran KM, Kantarjian HM, Kazmi SM, Quints-Cardama A, Cortes JE, Estrov Z, Ohanian M, Kadia TM, Borthakur G , Ravandi F, Pemmaraju N

In newborn mice, a single subcutaneous injection of N- nitroso- N -ethylurea caused lymphoma, liver cancer (hepatocellular carcinoma), and benign and malignant lung tumors (adenoma and adenocarcinoma) (IARC 1972c

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Conversely, we observed minimal dead cells in the CDCZA-treated group that had been pre-treated with NAC, resulting in no discernible difference from the PBS group