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It is a potent inhibitor of the enzyme NNMT, which plays a critical role in energy metabolism and fat storage within the body

[Google Scholar] Ranby B, Rabek JF

Patients with a history of long-term NSAID use who have developed gastric irritation or mucosal damage that persists despite stopping the NSAIDs

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It does not directly modulate GABA receptors, serotonin levels, or amygdala activity