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At 24 h post-transfection, cells incubated with TUNEL reaction mixture (37 C, 1 h, dark)

2B also suggest a gross change in the tertiary structure because of the observed decrease in CD signals at 269, 279, and 289 regions

Individualized titration is essential to achieve serum trough levels in the mid-normal physiologic range, thereby minimizing adverse effects such as erythrocytosis, gynecomastia due to aromatization, or suppression of endogenous spermatogenesis

It is closely linked to the phenotypic heterogeneity of cancer cells and helps them rapidly adapt to various injuries, facilitating drug resistance [114]
