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In the specific context of SCI, local ischemia and anoxia caused by trauma, together with the subsequent inflammatory response and surge of oxidative stress, lead to excessive activation of endoplasmic reticulum stress in spinal cord neurons and glial cells

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These growth abnormalities in LS patients without IGF-I substitutive treatment includes postnatal average growth rates of one-half the expected during the first years of life[19], a small brain (with prominent forehead, reduced vertical dimension of the face and hypoplasia of the midfacies and the nasal bridge), a small heart and acromicria[203] together with underdevelopment of the muscular system that delays walking in three-fourth of patients[204, 205], osteopenia at all stages (despite normal sex hormone status) with increased occurrence of avascular necrosis of the femoral head[206], impair and weaken skin, hair and nail growth[207], blue sclera due to the decreased thickness of its connective tissue, allowing visualization of the underlying choroid[205], a puberty delay from 3 to 7 years[206], retardation in the maturation of dentition[206] and high-pitched voice[208]

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A quick and effective way to increase B12 levels is with a shot or injection