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they are more likely to result from certain constituents of coffee augmenting endogenous antioxidant defences, such as upregulation of GSH concentration and glutathione-S-transferase (GST) activity (12)

Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-kappaB signaling pathway

Glutathione metabolism in Cryptocaryon irritans involved in defense against oxidative stress induced by zinc ions

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However, COX-2 is inducible in many cells in response to certain mediators of inflammation (e.g., interleukin-1, tumor necrosis factor, lipopolysaccharide, mitogens, and reactive oxygen intermediates)