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366 A meta-analysis of 12 randomized controlled trials with a combined total of 791 participants found acetyl-L-carnitine was more effective than placebo and had similar efficacy to widely-prescribed antidepressant drugs for reducing depression symptoms

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This effect also facilitates the infiltration of reactive-CD8+ T cells and improves the outcomes of T cell therapy (129)

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires mac-1-integrin