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Animal studies on albino Wistar strain rats showed that chronic high magnesium intake leads to thyroid disruption as it elevates thyroid peroxidase and Na(+)-K(+)-ATPase, changes iodothyronine 5-deiodinase type I activities, increases serum T4, tT3, and TSH, resulting in lowering fT3 and T3 and enlarging of the thyroid gland [118,119]