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FDA Registration Number: 86-1-04366-6-0005

Lentiviral-mediated shRNA interference All shRNAs for GCLC and SIRT2 were either from the reported literature [62] or designed and purchased from Sangon Biotech

doi: 10.1016/j.ecoenv.2022.114190 116

This mechanism occurs through butyrates ability to inhibit histone deacetylases (HDACs)

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