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However, practical experience suggests both approaches produce beneficial outcomes, with the choice often driven by convenience rather than optimization concerns

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

doi: 10.1016/j.iotech.2022.100070 66 StortiPVescoviniRCostaFMarchicaVToscaniDDalla PalmaBet al

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