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For example, a generational effect was observed in the penetrance of MC4R mutations in causing obesity, with younger generation having higher penetrance, likely due to the obesogenic environment of recent decades compared with decades surrounding World War II (430)

Use of Fecal Occult Blood Test in Hospitalized Patients: Survey of Physicians Practicing in a Large Central Canadian Health Region and Canadian Gastroenterologists

Furthermore, we note that S467C is a variant associated with SPCD 56 that has been shown to increase the K M for carnitine in cell uptake assays ~15-fold 57

Journal of the American College of Cardiology, 64 , 19081914

Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9