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In other tumors, such as melanoma, it has been documented that knock-out of this enzyme was responsible for elevated GSH disulfide (GSSG) levels in B16F10 cells [88]

Particularly, bone remodeling is temporally and spatially controlled and occurs continuously throughout the lifespan to maintain bone mass and architecture (5,7,20,27,29,30)

However, FOXO3a within the nucleus is limited

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[DOI] [PubMed] [Google Scholar] 114.Liu T., Zhang L., Joo D., Sun S.C