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Preprint at medRxiv (2020)

The synbiotic intervention was found to significantly modify the gut microbiota, increase the relative abundance of Lactobacillus , Bifidobacteria , and Subdoligranulum genera, substantially lower the serum level of IS, improve eGFR, and reduce the level of high-sensitivity C-reactive protein in the treated group

This arrangement results in residue Tyr518 from the oligomerisation loop slotting into a hydrophobic pocket formed by Leu423, Val425, Ile429, and Ile437 of -helix 15 (Supplementary Fig

C., Botros, F

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