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Zhou N, Rice DC , Tsao AS, Lee PP, Haymaker CL, Corsini EM, Antonoff MB, Hofstetter WL, Rajaram R, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Mehran RJ, Sepesi B

Although IM route of administration is less immunogenic than the SC route, IM injections have limitations with injectable volume and a higher risk with regard to patient tolerability The volume of medication that can be administered via IM injection is limited by the muscle tissues ability to absorb it

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J Neuroendocrinol (2004) 16(2):14653