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In a landmark study published in the Journal of Pharmacology and Experimental Therapeutics , researchers demonstrated that Dihexa drove new synapse formation in organotypic hippocampal slice cultures at concentrations as low as 10 molar (picomolar)

These data were validated via immunoblot analysis, which confirmed a 1.3-fold increase in 4-HNE labelling intensity of all putative 4-HNE modified proteins detected in the GV oocyte population ( p 0.0061

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