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With toxicity, manganese-induced damage is found in the substantia nigra, globus pallidus, and caudate nucleus with depletion of dopamine and serotonin levels and has been linked to psychiatric changes followed by impaired motor activity with muscle rigidity and tremors

Patel JP, Frey BN

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molecules (Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

The link to autoimmune disease is leaky gut and many patients with MTHFR polymorphisms have imbalanced microbes in the gut which lead to dysbiosis and autoimmune disease -you can read more about that link here My husband and I are both negative for C677T, but both hetero for A1298C