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Penny LK, Wallace HM

In contrast, LCCN is associated with mainly Bence Jones proteinuria often with 1 g/d proteinuria with 150 mg/dl, the probability of LCCN is high enough that a kidney biopsy can be omitted [7, 26, 27]

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Advances in detailed structural information (Qi et al., 2019) as well as computational homology modeling and mutational analysis of ligand-binding regions (Bhatia et al., 2023) will provide further direction to drug discovery for selective targeting of cardiovascular ACs, as will the selection of appropriate pharmacokinetic features and targeted drug delivery systems to decrease off-target adverse effects

For a step-by-step overview, see What to Expect at California Infusion Centers