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191 Once-daily administration of roflumilast significantly improves forced expiratory volume in 1 s and decreases exacerbations, particularly in patients with severe disease, 192,193 but has side effects such as nausea, vomiting and headache

With respect to amino acid uptake, expression of the heterodimeric neutral amino acid transporter CD98 on CMV-specific CD8 + T cells was decreased in noncontrollers compared with controllers (Figure 3D), which is in accordance with decreased gene expression of SLC7A5 , encoding for 1 part of the heterodimer, in noncontrollers (Figure 2, BD)

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