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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

In a multicenter, phase 3 clinical trial, 300 mg of subcutaneous mepolizumab led to a significantly increased duration of remission, and a larger proportion of patients remained in remission at weeks 36 and 48 compared to the placebo group (43)

further developed nanostructure-initiator MS (NIMS), which uses liquid initiators to facilitate desorption

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898 Furthermore, by integrating CRISPR/cas9 gene-editing technology with various sequencing, researchers can conduct high-throughput functional genomic screens and identify pathological genes that are responsive to epigenetic therapies