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In sepsis, the gut lymphatic vessels play a dual role, they act as a conduit for the transfer of pathogens from the gut to distant organs, and they contribute to the systemic inflammatory response through dissemination of pro-inflammatory cytokines to other parts of the body [119]

This provides an oxygen sensing mechanism in which high oxygen concentration increases hydroxylation of prolyl residues leading to ubiquitination and proteolytic degradation of HIF [137]

Although individual NADPH-dependent pathways are well characterized, how these opposing pathways are co-regulated to orchestrate an optimized inflammatory response is not well understood

Discontinue use if irritation or rash appears

Typical oral protocols use 0.5 mg to 1 mg daily, often split into two doses taken morning and evening