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Analogue 1j [bearing N, N-dimethylamino and alkoxy substituents] maximises hydrophobic contacts in the ATP pocket notably engaging Ile294 deeply and contacting Val163 and Ala176 on the kinase hinge

Kapetanaki S, Kumawat AK, Persson K, Demirel I (2021) The fibrotic effects of TMAO on human renal fibroblasts is mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR pathway

Most treatments involve minimal or no downtime

doi: 10.1111/jgh.14362 96 JangSEHanMJKimSY

By sensitizing tumors to genotoxic therapies while offering protection to normal cells, rhamnetin has the dual advantage of improving therapeutic outcomes while minimizing toxicity