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This cysteine-homocysteinylation event perturbs the pro-insulin receptor and furin protease interaction within the Golgi apparatus, consequently inhibiting the cleavage of the pro-insulin receptor
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Polyakova, E
Furthermore, sustained radical stress inflicts widespread structural damage on organelles, most critically the mitochondria, through mechanisms like cardiolipin peroxidation (which disrupts cristae architecture) and mitochondrial DNA (mtDNA) mutations [9497]
