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Hormonal Changes Hormonal fluctuations during pregnancy or while undergoing hormonal therapy can trigger excess melanin production

It is estimated that, by 2030, this number will rise to 643 million [97]

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Studies have shown that DCs are primarily found in synovial fluid, mainly as mature cDCs (conventional DCs derived from myeloid stem cells) and immature pDCs (plasmacytoid DCs derived from lymphoid stem cells), and play a unique role in cartilage damage (102)

However, 8-MOP was found to act as a promising GST inhibitor (Figure 9B) [192,193]
