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13 Cryotherapy delivered in freeze-thaw cycles (Table 2) is effective at destroying malignant cells in superficial BCC because cellular damage occurs both during the freezing process and during the slower thaw, due to the osmotic gradient across the cell membrane

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histologically, melanoma in situ is defined as the presence of a pagetoid spread of malignant melanocytes throughout the epidermis

Melanoma Melanoma: Melanoma is characterized by the uncontrolled growth of melanocytes, cells that produce melanin (pigment) in the skin

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