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But IRL, theres no evidence to back that up

It begins with degenerative changes in the distal reaches of the affected fibers and fairly characteristically involves the largest and longest, such as the proprioceptive and motor tracts of the spinal cord, optic tract, and recurrent laryngeal and other long peripheral nerves

Moreover, they imply that lysosomes can assume an anti-inflammatory role by becoming a source of a ribosome-derived miRNA that enables a unique mode of metabolic regulation, delaying premature ER stressassociated responses to optimize cellular metabolic adaptation