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It is appropriate for trials involving investigational products (including drugs, biologics, and medical devices) that do not require prior approval from the Therapeutic Goods Administration (TGA)

[DOI] [PubMed] [Google Scholar] 14.Allocati N., Masulli M., Di Ilio C., Federici L

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Acetylcysteine should be continued beyond the protocol length until acetaminophen concentrations are undetectable, serum AST has normalized or significantly improved, and there is resolution of any evidence of hepatic failure