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Namely, an increase in heme oxygenase 1 (HO-1) activity in breast cancer cells leads to a transient release of free iron and a consequent increase in ROS content, promoting the expression of matrix metalloproteinase 1 and cell migration [76]

In the transformation of hemorrhage after cerebral ischemia, iron overload significantly decreases oxidation metabolism, lactic acid generation, and brain pH value, further increasing iron release