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In-depth studies of gut flora in recent years have shown that bacterial translocation and the existence of bacterial active products in blood circulation can affect the inflammatory state of the whole blood vessel

Although in WT, HSP-16.1 and HSP-16.2 undergo 350-fold and 1,700-fold up-regulation at transcript level, in the ctl-2(ua90)II mutant, they increase only 40-fold and 70-fold, respectively

Consequently, histone acetylation at distinct locations may assume disparate roles in diverse neuronal subtypes (e.g., DA, 5-HT, Glu neurons), offering novel insights into the intricate mechanisms underlying METH addiction

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