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doi: 10.1073/pnas.1421204112
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130 Comparatively, the deficiency of ZIP8 has a substantial impact on zinc influx in effector T cells and results in reduced TCR-mediated signaling, including NF-B and MAPK signaling, which are involved in the differentiation of T helper (Th)17 cells
Genetic variations in VDBP/( CYP2R1 ) are known to influence 25(OH)VD blood levels in response to VD supplementation (13, 19, 23, 29, 30, 52)
Additionally, the inhibitor treatment reduced glutathione and cysteine uptake in MDSCs, indicating that it targets glutathione synthesis from cysteine [53]
