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Nevertheless, several attempts have been made over the years to try to decrease the oxidative stress that plays a great part in its progression

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In addition to selecting the appropriate cell type, SCTs must address challenges related to the purity and viability of isolated cells, as contamination or cell death can undermine treatment effectiveness [148]

Furthermore, metabolic comorbidities such as insulin resistance indirectly enhance urate reabsorption through NHE3-mediated (sodiumhydrogen exchanger 3) tubular alkalinization, creating a mechanistic link between metabolic syndrome and hyperuricemia (Gong et al., 2020

Certain probiotic strains (Lactobacillus rhamnosus JB,1) influence GABA receptor expression in the brain and mitigate stress-induced behaviors in animal models [103]