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Extended continuous exposure to any signaling molecule can lead to receptor downregulation, where cells reduce sensitivity to maintain homeostasis
these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1
In: Vitamin and Mineral Requirements in Human Nutrition: Report of a Joint FAO/WHO Expert Consultation
It was historically common but has been largely replaced by thinner options
doi: 10.1016/j.foodres.2021.110468
