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Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: A randomized, single-blind, placebo-controlled trial

Metabolic acidosis alters the redox state of mitochondrial nicotinamide adenine dinucleotide (NAD) and causes mitochondrial stress in renal proximal tubules, which affects lipid metabolism [21, 82]

Side effects are rare but may include mild discomfort at the injection site or a slight rash

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1173 Inhibiting HK1 and HK2 with lonidamine has been shown to alleviate joint damage in collagen-induced arthritis models 1174 while reducing IL-1 and TNF- levels and restoring macrophage anti-inflammatory functions in RA models