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doi: 10.3389/fphar.2025.1639698 Received 02 June 2025 Revised 11 October 2025 Accepted 20 October 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Maria Yelshanskaya, Columbia University, United States Reviewed by Linda Marie Nowak, Cornell University, United States Yue Zeng, Chinese Academy of Sciences (CAS), China Updates Copyright 2025 Garca-Daz, Castellanos, Miguez-Cabello, Picaol, Prez-Gonzlez, Gratacs-Batlle, Vega-Castro, Altafaj, Reyes-Guzmn, Reyes-Montao, Gasull and Soto

Chen ZS, Tiwari AK

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Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells

The various glucose-modified PIC/Ms improved brain by-products owing to their multivalent interaction with GLUT1 located on the brain capillary endothelial cells ( in vitro RNA interference using HF-1 cells ( in vivo research indicates that nanoparticles based siRNA therapies have proven effective as targeted AD therapeutics ( 7.2 NP-strategy for ALS therapeutics A promising approach is to improve drug delivery for ALS through targeted, nano-enabled drug delivery systems, such as polymeric nanoparticles (Figure 3)