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We further investigated how GGsTop affected the downstream inflammatory pathways and outlined the role of GGTs in asthma exacerbation

MTX inhibits key enzymes of folate metabolism, including DHFR, thymidylate synthase, MTHFR and SHMT (57,58)

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In the absence of myelin, redistribution of Na + occurs to maintain the transmission of nerve impulses that increases energy demand, and this produces a situation of virtual hypoxia. At the end, the demand exceeds the capacity of axonal mitochondria to produce enough ATP, which causes an increase in the concentration of Ca 2+ in the axon